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1.
Variation of, "you are a liar" or "quit clowning". Indeginous to the American South, specfically Mississippi.
As Jimbo ends his "Yo Mama" joke ( directed towards Leroy), Leroy counters with, "You a lie."
av millhouse 7 maj 2004
 
2.
Something some students in Washington say when a friend, family member, etc tells a lie.

Roots: "You a Lie" is used most frequently, and was brought up from the TV show "Meet the Browns."
Josh: So what did you do in Arizona?

Jacob: I invented the teleportation device.

Josh: YOU A LIE!
av JPdude6 9 april 2010