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1.
to overreact completely, to freak-out, to go mental.
"She heard about what her friend did and went totally spazzcakes."
av yeller9 14 november 2007
 
2.
Noun. A person who has either had far too much caffeine or is very unusual and/or silly.
"Gia is a spazzcake."
av Belle-Zizi 29 december 2006
 
3.
A state of extreme emotional and intellectual disorientation.
Laura came home from the bar last night, couldn't find her masking tape, and then went totally spazzcakes - she was rolling on the floor in hysterics.
av Lauchlin 1 november 2007