Top Definition
is somethin that Indians used to smoke back in the day at rituals to see spirits. (its really shrooms in weed form)
the indians smoked payote and began seein crazy images.
av Britanni 24 september 2008
1 more definition
A type of weed- I am not sure of the root of this word, but it was used by my roomate yesterday.
My friend and I were looking for Payote last night.
av BeccaSchmehcca 1 april 2006

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