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1.
A surgical incision into the frontal lobe of the brain to sever one or more nerve tracts, a technique formerly used to treat certain mental disorders but now rarely performed.
Hannibal Lector gave a lobotomy to Ray Liotta in Hannibal
av Junkyardjimbo88 7 juli 2003
 
2.
1) removal of the frontal lobe of the brain, causing the "patient" to lose all capacity for higher thought, reason, etc. while still technically not considered a "vegetable".

2) a process that had been deemed unethical and barbaric, but has evidently been stealthily carried out on a truly massive scale, as shown by tell-tale symptoms of lobotomization such as:

"Calvin pissing" stickers, voting Republican, obsessive interest in NASCAR, membership in the NRA (as opposed to responsible hunting, fishing, and conservation groups), calling it "moral values" to tell lies in order to start unnecessary wars that kill or maim tens of thousands of people as well as to lie, cheat, and embezzle in a manner befitting of Enron, Halliburton, Arbusto Energy, or Tyco, to destroy God's Creations with irresponsible & reckless abandon, especially while simultaneously ignoring all principles of science and all available facts in order to promote a theocratic worldview in the guise of "intelligent design" (an indoctrination ironically similar to the Islamic fundamentalist wackos these same so-called Christians purport to be opposed to), promote the hatred of and discrimination against the economically disenfranchised or otherwise most vulnerable members of a society, particularly if it allows titillating discussion of sexual acts these same repressed prudes and closet-cases secretly fetishize under the flimsy pretense of "taking a moral stand".
That Dubya's a walking, talking lobotomy.
av FunkyBumpkin 29 april 2005
 
3.
an operation used to treat certain mental disorders
i would rather get a lobotomy than listen to avril lavigne.
av wakkawakka 16 oktober 2003
 
4.
a quick treatment for mental disorders that gets right to the point
I'd rather have a bottle in front of me than a frontal lobotomy.
av mandingoh 10 december 2004
 
5.
A location where scientists perform experiments in order to make advancements in the scientific community.
In 1934, when Jimmy was in his lobotomy fiddling around with his friend Horatio and a saw, he inadvertently performed the first laboratory.
av Phrogger 1 april 2006
 
6.
if one is successfully able to insert their head into a menstrating vagina, making sure that the head is covered in blood
Congradulations, sir. Your lobotomy was an incredible success.
av Standford 14 augusti 2006