Top Definition
when ones pancreas explodes (from duff mckagan of guns n' roses)
dude i was wasted last night i fucked like 4 chinese prostetutes then my pancreas duff'd
#pancreas #duff #mckagan #fucked #chinese
av larry122 23 april 2006
Duff'd (v) - The act of getting used and or manipulated by an attractive, mentally unstable person of the opposite sex. Unfortunately this includes an abundance of flirting, profound mixed messages, and sexual enuendos that don't actually lead to SEX, merely the illusion that it will. The Duff usually ends by the Duff-er getting back together with their original girl/boyfriend, leaving the duff-ee with a killer case of blue balls/dry-gina.



Man, I thought this relationship was going to go somewhere, but really I was just totally getting Duff'd!
#played #rebounder #blue-balls #jamesed #emotional crutch
av DFaFH 7 april 2006
When something goes horribly wrong, as in when Hillary Duff was given a recording contract.
1) Did you see that guy get hit by that truck? Man, that was duff'd.

2) That girl's face is duff'd.
av Mirage 31 december 2004
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