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1.
Used to metaphorically describe a difficult situation, as in hard schoolwork.

The word struggle can also be used in conjunction with other modes of transport, describing the depth to which one is struggling(i.e. struggle scooter, struggle skateboard, struggle footwear).
Student: "Y'all, I have 6 papers and 4 tests within the next 2 weeks. Definitely on that struggle bus!"
av VADyme 16 april 2009
 
2.
The state of doing anything simple and struggling an inordinate amount with it. Tends to happen after a long period of time without sleep.
Wow, I'm really riding the strugglebus today.
av m. night rider 14 februari 2011
 
3.
A metaphor for when you repeatedly struggle to do basic tasks. Can't find your keys and they are in your hand, opening doors into yourself, locking keys in your car, etc.
Man 1: "I can't find my glasses or my keys"
Man 2: "You are wearing your glasses and your keys in your hand"
Man 1: "Ya, I'm driving that struggle bus today"
av SoloTree 25 juli 2013
 
4.
The state of struggling after drinking so much to the point that you don't know where you are or how you're walking.
Man after that last shot of Captain I hopped on the strugglebus and rode it all the way home.
av Jschramm23 18 oktober 2010
 
5.
A generic conceptual term for the vehicle or conveyance used to get to work or school after a late night of partying, especially when accompanied by a hangover.
- Carly looks like shit!
- Yeah, she took the struggle bus into work today.
av G-Money 31 augusti 2007
 
6.
Phrase used by the upper middle class to imply that they have a difficult life.
"I'm on the struggle bus. My dad bought me the wrong color iPhone."
"I'm on that struggle bus because one of my six beach houses was destroyed by hurricane Sandy."
av The One, The Only 23 augusti 2013
 
7.
When retailers can't keep up with the rest of the stores and seem to be failing. (In need of some help)
Eddie Bauer just filed for bankruptcy. It's offical, they are on the struggle bus.
av hoolahoop57 13 juli 2009