Top Definition
A generic phrase to describe any sexually transmitted disease, or as a shorthand to describe having multiple STDs. Some dispute exists as to the proper spelling, but either "Big Louie" or "Big Louis" is acceptable.
Dude, if a chick ever makes you get tested for the Big Louie, make sure to piss in the cup instead of letting them stick that huge q-tip in there, that shit hurts.
av No Big Louie 16 november 2006

Gratis daglig E-post

Skriv in din E-post adress nedan för att få vårt gratis Urban ord för dagen varje morgon!

E-posten är sänd från daily@urbandictionary.com. Vi kommer aldrig spamma dig.

×