When someone of great skill decides to change their location to play for a better team, company, etc. This was started by LeBron James in his televised decision special when he announced he was going to Miami. It usually thought of as a very douchy and selfish move and does not necessarily have to be about moving to Miami. Can also be used as a euphemism for taking a crap.
After giving it a lot of thought, I've decided to take my talents to South Beach.
Hey man, you got any toilet paper? I need to go take my talents to South Beach.